General consideration
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1. Clomiphen citrate (clomid, serophen)
a. nature : synthetic, nonsteroidal, biologically weak long-acting estrogen agonistb. action : competitive inhibitor of estrogen
blocking estrogen Rc at the hypothalamic & pituipaty level- increase FSH release from pituitary by (-) feedback
c. criteria for the selection of patients for clomid
① evidance of pituitary fx
② no evidance of primary ovarian failure
③ normal prolactin assay
④ normal thyroid & adrenal fx
⑤ no other treatable cause of amenorrhea
⑥ no obvious infertility factor
d. dosage & duration
: 50-100 mg/day for 5-10 days from cycle day 3-5(dosage↑- FSH 보강, duration↑- LH 보강)
e. monitoring
: BBT(basal body temperature, 일어나자 마자 움직이지 말고 혀 밑에서 잼)cervical mucus(clomiphen day 12-14), E2, LH, ultrasonogram, P4,
endometrial Bx(clomiphen day 25-27)
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① daily dose 증가 (FSH 증가)
② duration 증가 (poor estrogenic mucus -- LH 증가)
③ administration of hCG
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a. nature : synthetic, nonsteroidal, bi...
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General consideration
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1. Clomiphen citrate (clomid, serophen)a. nature : synthetic, nonsteroidal, bi... , General consideration기타레포트 ,
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1. Clomiphen citrate (clomid, serophen)
다.